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科研团队(中心实验室):杨恭 副主任(主持工作)
发布日期.[2018-08-14] 来源:  浏览:23828

学位研究:

2001年毕业于中国科学院微生物研究所,微生物学,博士学位 (师从田波院士与邱并生研究员)

博士后研究:

2001.9-2002.4 Rice University-Howard Hughes Medical Institute, Houston, Texas, USA

2002.4-2005.4 the University of Texas MD Anderson Cancer Center, Houston, Texas, USA

工作经历:

2005.5-2008-5 美国德克萨斯大学MD安德森癌症研究中心病理系,讲师

2008.6-2010.8 美国德克萨斯大学MD安德森癌症研究中心病理系,助理教授

(2012.5-2012.8 日本金沢大学癌症研究所,公派访问教授)

2010.9-2013.12 复旦大学附属肿瘤医院,教授,博士生导师,研究中心/所 副主任;复旦大学附属上海市第五人民医院,特聘教授,中心实验室常务副主任

2013.7-至今  复旦大学附属肿瘤医院/复旦大学附属上海市第五人民医院,教授/特聘教授,中心实验室常务副主任

荣誉和奖励:

1999年  获中国科学院微生物所所长奖学金三等奖

2000年  获中国科学院微生物所所长奖学金二等奖

2000年  获中国科学院地奥奖学金一等奖

2001年  获北京植物病理协会优秀论文一等奖

2001年  获第四届北京青年优秀科技论文二等奖

2011年  美国MD安德森癌症中心全球科学项目青年研究员奖

会议发言与被邀学术报告:

2005年4月  美国AACR会议(洛杉矶)分会场发言,Knockdown of tumor suppression genes combined with expression of the catalytic subunit of telomerase to immortalize primary human cells.
2008年9月  天津医科大学总医院/肺癌研究所,Ovarian cancer, from senescence to immortalization and transformation
2008年9月  中国医学科学院肿瘤医院,NF-?B signaling in ovarian cancer
2008年10月 南京医科大学,RAS signaling in ovarian cancer
2008年10月 新疆石河子大学医学院,Mouse models of Ovarian cancer
2008年10月 北京大学医科院,Cell senescence and ovarian cancer
2010年10月 中华医学会老年医学分会年会,贵州遵义,间质细胞衰老与卵巢癌的发生 
2010年12月 上海市肿瘤研究所,Stromal cell senescence and RAS signaling in ovarian cancer development
2011年5月  中华医学会老年医学分会年会,辽宁沈阳,NF-kB调节细胞衰老与卵巢癌发生的机理
2011年6月  美国MD安德森癌症中心全球学术会议,Biphasic role of NF-kB in ovarian cancer development
2011年10月 上海市妇产科学会年会,卵巢癌细胞转化模型的构建
2011年12月 人口老化与相关疾病预防-香山科学会议,北京,间质细胞衰老与肿瘤发生
2012年6月  日本金泽大学癌症研究所,Ovarian cancer: models and beyond
 2012年11月 中国医学科学院肿瘤医院,Aurora-A激酶与BRCA2调节细胞有丝分裂导致染色体不稳定性发生的机制 
2013年10月第二届中国乳腺癌干细胞高峰论坛,云南丽江,Fibroblast senescence and epithelial cancer stem cells

参会摘要:

2003-2005年美国AACR年会会议摘要,共6篇

2007-2010年美国AACR年会会议摘要,共5篇

审稿杂志:

Clinical Cancer Research

Journal of Molecular Medicine

Molecular Cancer Therapeutics

Cancer Medicine

Cancer Cell International

Tumor Biology

Cell Cycle

Plos On

在美课题:

美国MD安德森癌症中心乳腺癌SPORE项目:

1、Function of CXCR2 in breast cancer, PI (50K$), 2008-2009

2、Investigation of EMSY in breast cancer, Co-PI (100K$), 2006-2009

专业会员:

国际:美国癌症研究学会会员, 2003-至今。

国内:

1、中国老年保健医学研究会老年健康与转化医学分会-委员

2、中国生物化学与分子生物学会脂质与脂蛋白专业委员会-委员

3、中华医学会肿瘤上海市肿瘤协会靶分子治疗专业委员分会-委员

研究方向:

1、 间质细胞衰老与上皮细胞恶性转化

2、 卵巢癌细胞永生化与转化动物模型构建及分析

3、 乳腺癌与卵巢癌等肿瘤微环境细胞因子及其受体促进肿瘤转移复发与放化疗抵抗的机理

4、 RAS/P53相关基因突变与细胞糖代谢、脂代谢和线粒体能量代谢及其干预策略

5、 肿瘤靶向药物的筛选与开发

科研成果:

先后发表SCI论文40多篇。现主持国家自然科学基金、教育部课题和上海市科委课题5项。

发表论文;
1. Qi Z, Liu M, Liu Y, Zhang M, Yang G**, Tetramethoxychalcone, a chalcone derivative, suppresses proliferation, blocks cell cycle progression, and induces apoptosis of human ovarian cancer cells, Accepted by PLOS ONE 2014.
2. Yang L, Zhou Y, Wu Y, Cui Y, Yang G**, and Hong Y. p53 deficiency and KRAS mutation synergistically activate NF-kB to promote chemoresistance and tumorigenesis via dysregulation of cell cycle and suppression of apoptosis in lung cancer cells. Accepted by Cancer Letters 2014
3. Wang Z, Liu Y, Yang L, Yin S, Zang R, Yang G**. The polymorphism interleukin-8 -251A/T is associated with a significantly increased risk of cancers from a meta-analysis. Tumour Biol. 2014 Jul;35(7):7115-23. doi: 10.1007/s13277-014-1881-5. Epub 2014 Apr 24.
4. Qian Y, Wang Y, Ji Q, Yang G**. The chemokine receptor- CXCR2 plays a critical role in the invasion and metastasis of oral squamous cell carcinoma in vitro and in vivo. J Oral Pathol Med. 2014 Jun 23. doi: 10.1111/jop.12189. [Epub ahead of print].
5. Hou J, Wang Z, Yang L, Guo X, Yang G**. The function of EMSY in cancer development. Tumour Biol. 2014 Jun;35(6):5061-6. doi: 10.1007/s13277-013-1584-3. Epub 2014 Mar 9.
6. Wang Y, Wang Z, Qi Z, Yin S, Zhang N, Liu Y, Liu M, Meng J, Zang R, Zhang Z, Yang G**. The negative interplay between Aurora A/B and BRCA1/2 controls cancer cell growth and tumorigenesis via distinct regulation of cell cycle progression, cytokinesis, and tetraploidy. Mol Cancer. 2014 Apr 28;13:94. doi: 10.1186/1476-4598-13-94.
7. Sun H, Wang Y, Wang Z, Meng J, Qi Z, Yang G**. Aurora-A controls cancer cell radio- and chemoresistance via ATM/Chk2-mediated DNA repair networks. Biochim Biophys Acta (Molecular Cell Research). 2014 Jan 28. pii: S0167-4889(14)00031-7. doi: 10.1016/j.bbamcr.2014.01.019. [Epub ahead of print]
8. Wang Y, Sun H, Wang Z, Liu M, Qi Z, Meng J, Sun J, Yang G**. Aurora-A: a potential DNA repair modulator. Tumour Biol. 2014 Apr;35(4):2831-6. doi: 10.1007/s13277-013-1393-8. Epub 2013 Nov 26.
9. Wang Z, Hou J, Lu L, Qi Z, Sun J, Gao W, Meng J, Wang Y, Sun H, Gu H, Xin Y, Guo X, Yang G**. Small ribosomal protein subunit S7 suppresses ovarian tumorigenesis through regulation of the PI3K/AKT and MAPK pathways. PLoS One. 2013 Nov 11;8(11):e79117. doi: 10.1371/journal. pone.0079117. eCollection 2013.
10. Chen Y, Ke G, Han D, Liang S, Yang G, Wu X. MicroRNA-181a enhances the chemoresistance of human cervical squamous cell carcinoma to cisplatin by targeting PRKCD. Exp Cell Res. 2014 Jan 1;320(1):12-20. doi: 10.1016/j.yexcr.2013.10.014. Epub 2013 Oct 31.
11. Ren C, Cheng X, Lu B, Yang G**. Activation of interleukin-6/signal transducer and activator of transcription 3 by human papillomavirus early proteins 6 induces fibroblast senescence to promote cervical tumourigenesis through autocrine and paracrine pathways in tumour microenvironment. Eur J Cancer. 2013 Dec;49(18):3889-99. doi: 10.1016/j.ejca.2013.07.140. Epub 2013 Aug 15.
12. Lin F, Luo J, Gao W, Wu J, Shao Z, Wang Z, Meng J, Ou Z, Yang G**. COX-2 promotes breast cancer cell radioresistance via p38/MAPK-mediated cellular anti-apoptosis and invasiveness. Tumour Biol. 2013 Oct;34(5):2817-26. doi: 10.1007/s13277-013-0840-x. Epub 2013 Jun 15.
13. Yang G**, Mercado-Uribe I, Multani AS, Sen S, Shih IM, Wong KK, Gershenson DM, Liu J. RAS Promotes Tumorigenesis through Genomic Instability Induced by imbalanced expression of Aurora-A and BRCA2 in midbody during cytokinesis. Int J Cancer. 2013 Jul 15;133(2):275-285. *(第一作者和通讯作者).
14. Shi TY, Yang L, Yang G, Tu XY, Wu X, Cheng X, Wei Q. DNA polymerase ζ as a potential biomarker of chemoradiation resistance and poor prognosis for cervical cancer. Med Oncol. 2013 Jun;30(2):500.
15. Shi TY, Yang G, Tu XY, Yang JM, Qian J, Wu XH, Zhou XY, Cheng X, Wei Q. c RAD52 variants predict platinum resistance and prognosis of cervical caner.PLoS One. 2012;7(11):e50461.
16. Guo X, Liu G, Schauer, IG, Yang G, Mercado-Uribe,I, Yang F, Zhang,S, He Y, Liu J, Over-expression of the beta subunit of human chorionic gonadotropin promotes the transformation of human ovarian epithelial cells and ovarian tumorigenesis. Am J Pathol. 2011 Sep;179(3): 1385-93.
17. Yang F, Guo X, Yang G, Rosen DG and Liu J.AURKA and BRCA2 expression highly correlate with prognosis of endometrioid ovarian carcinoma. Modern Pathology. 2011 Mar 25.
18. Yang G, Xiao X, Rosen DG, Cheng X, Wu X, Chang B, Liu G, Xue F, Mercado- Uribe I, Chiao PJ, Du X, Liu J. The Biphasic Role of NF-{kappa}B in Tumor Progression and Chemoresistance of Ovarian Cancer. Clin Cancer Res. 2011 Apr 15;17(8):2181-94.
19. Cheng X, Yang G, Schmeler KM, Coleman RL, Tu X, Liu J, Kavanagh JJ. Recurrence patterns and prognosis of endometrial stromal sarcoma and the potential of tyrosine kinase-inhibiting therapy. Gynecol Oncol. 2011 May 1;121(2):323-7.
20. Yang G, Rosen DG, Liu G, Yang F, Guo X, Xiao X, Xue F, Mercado-Uribe I, Huang J, Lin SH, Mills GB, Liu J. CXCR2 promotes ovarian cancer growth through dysregulated cell cycle, diminished apoptosis, and enhanced angiogenesis. Clin Cancer Res. 2010 Aug 1;16(15):3875-86.
21. Liu G, Yang G*, Chang B, Mercado-Uribe I, Huang M, Zheng J, Bast RC, Lin SH, Liu J. Stanniocalcin 1 and ovarian tumorigenesis. J Natl Cancer Inst. 2010 Jun 2;102(11):812-27. (*co-first author)(共同第一作者)
22. Yang G, Chang B, Yang F, Guo X, Cai KQ, Xiao XS, Wang H, Sen S, Hung MC, Mills GB, Chang S, Multani AS, Mercado-Uribe I, Liu J. Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. Clin Cancer Res. 2010 Jun 15;16(12):3171-81.
23. Zheng J, Mercado-Uribe I, Rosen DG, Chang B, Liu P, Yang G, Malpica A, Noara H, Auersperg N, Mills GB, Bast RC, Liu J. Induction of papillary carcinoma in human ovarian surface epithelial cells using combined genetic elements and peritoneal microenvironment. Cell Cycle. 2010, Jan 1;9(1):140-6.
24. Xiao X, Bai P, Bui Nguyen TM, Xiao J, Liu S, Yang G, Hu L, Chen X, Zhang X, Liu J, Wang H. The antitumoral effect of Paris Saponin I associated with the induction of apoptosis through the mitochondrial pathway. Mol Cancer Ther. 2009 May 12.
25. Shan W, Yang G, Liu J . The inflammatory network: bridging senescent stroma and epithelial tumorigenesis. Front Biosci. 2009 Jan 1;14:4044-57.
26. Rosen DG, Yang G, Liu G, Mercado-Uribe I, Chang B, Xiao XS, Zheng J, Xue FX, Liu J.  Ovarian cancer: pathology, biology, and disease models.  Front Biosci. 2009 Jan 1;14:2089-102
27. Chang B, Liu G, Yang G, Mercado-Uribe I, Huang M, Liu J. REDD1 is required for RAS-mediated transformation of human ovarian epithelial cells. Cell Cycle. 2009 Mar 1;8(5):780-6. Epub 2009 Mar 20.
28. Wang D, Zhao Z, Caperell-Grant A, Yang G, Mok SC, Liu J, Bigsby RM, Xu Y. S1P differentially regulates migration of human ovarian cancer and human ovarian surface epithelial cells. Mol Cancer Ther. 2008 Jul;7 (7):1993-2002.
29. Zhang Z, Singh M, Davidson S, Rosen DG, Yang G, Liu J. Activation of BTAK expression in primary ovarian surface epithelial cells of prophylactic ovaries. Mod Pathol. 2007 Oct; 20(10):1078-84.
30. Yang G, Rosen DG, Colacino JA, Mercado-Uribe I, Liu J. Disruption of the retinoblastoma pathway by small interfering RNA and ectopic expression of the catalytic subunit of telomerase lead to immortalization of human ovarian surface epithelial cells. Oncogene. 2007 Mar 1; 26(10): 1492-8.
31. Young TW, Mei FC, Rosen DG, Yang G, Li N, Liu J, Cheng X. Up-regulation of Tumor Susceptibility Gene 101 Protein in Ovarian Carcinomas Revealed by Proteomics Analyses. Mol Cell Proteomics. 2007 Feb; 6(2): 294-304.
32. Yang G, Rosen DG, Mercado-Uribe I, Colacino JA, Mills GB, Bast RC Jr, Zhou C, Liu J. Knockdown of p53 combined with expression of the catalytic subunit of telomerase is sufficient to immortalize primary human ovarian surface epithelial cells. Carcinogenesis. 2007 Jan; 28(1): 174-82.
33. Rosen DG, Mercado-Uribe I, Yang G, Bast RC Jr, Amin HM, Lai R, Liu J. The role of constitutively active signal transducer and activator of transcription 3 in ovarian tumorigenesis and prognosis. Cancer. 2006 Dec 1; 107(11): 2730-40.
34. Wen XF, Yang G, Mao W, Thornton A, Liu J, Bast RC Jr, Le XF. HER2 signaling modulates the equilibrium between pro- and antiangiogenic factors via distinct pathways: implications for HER2-targeted antibody therapy. Oncogene. 2006 Nov 2; 25(52): 6986-96.
35. Yang G, Rosen DG, Zhang Z, Bast RC Jr, Mills GB, Colacino JA, Mercado-Uribe I, Liu J. The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44): 16472-7.
36. Rosen DG, Yang G, Deavers MT, Malpica A, Kavanagh JJ, Mills GB, Liu J. Cyclin E expression is correlated with tumor progression and predicts a poor prognosis in patients with ovarian carcinoma. Cancer. 2006 May 1; 106(9): 1925-32.
37. Rosen DG, Yang G*, Bast RC Jr, Liu J. Use of ras-transformed human ovarian surface epithelial cells as a model for studying ovarian cancer. Methods Enzymol. 2005; 407: 660-76. (*co-first author)
38. Hu Y, Rosen DG, Zhou Y, Feng L, Yang G, Liu J, Huang P. Mitochondrial anganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress. J Biol Chem. 2005 Nov 25; 280(47): 39485-92.
39. Rosen DG, Yang G, Cai KQ, Bast RC Jr, Gershenson DM, Silva EG, Liu J. Subcellular localization of p27kip1 expression predicts poor prognosis in human ovarian cancer. Clin Cancer Res. 2005 Jan 15; 11(2 Pt 1): 632-7.
40. Young TW, Mei FC, Yang G, Thompson-Lanza JA, Liu J, Cheng X. Activation of antioxidant pathways in ras-mediated oncogenic transformation of human surface ovarian epithelial cells revealed by functional proteomics and mass spectrometry. Cancer Res. 2004 Jul 1; 64(13): 4577-84.
41. Liu J, Yang G, Thompson-Lanza JA, Glassman A, Hayes K, Patterson A, Marquez RT, Auersperg N, Yu Y, Hahn WC, Mills GB, Bast RC Jr. A genetically defined model for human ovarian cancer. Cancer Res. 2004 Mar 1; 64(5): 1655-63.
42. Ehrenman K, Yang G, Hong WP, Gao T, Jang W, Brock DA, Hatton RD, Shoemaker JD, Gomer RH. Disruption of aldehyde reductase increases group size in dictyostelium. J Biol Chem. 2004 Jan 9; 279(2): 837-47.
43. Yang G, Cai KQ, Thompson-Lanza JA, Bast RC Jr, Liu J. Inhibition of breast and ovarian tumor growth through multiple signaling pathways by using retrovirus-mediated small interfering RNA against Her-2/neu gene expression. J Biol Chem. 2004 Feb 6; 279(6): 4339-45.
44. Yang G, Thompson JA, Fang B, Liu J. Silencing of H-ras gene expression by retrovirus-mediated siRNA decreases transformation efficiency and tumor growth in a model of human ovarian cancer. Oncogene. 2003 Aug 28; 22(36): 5694-701.
45. 2、Investigation of EMSY in breast cancer, Co-PI (100K$), 2006-2009