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科研团队(中心实验室):郭熙志
发布日期.[2015-01-26] 来源:  浏览:22727

简介:上海交通大学特聘教授,Bio-X研究院 骨骼发育与疾病组组长

教育:

1997.9-2002.7    博士. 中科院上海植物生理生态研究所, 分子遗传学

1993.9-1997.7    学士. 武汉大学, 遗传学

工作经历:

2008-现在        特聘教授  上海交通大学Bio-X研究院,发育遗传学  

2003.1-2007.11  博士后  美国国立卫生研究院访问学者, 发育遗传学

参与专业协会

2000  中国植物生理学会会员

2004  美国细胞学学会会员

2010  美国神经学会会员

2005-2011  美国骨骼及骨矿物质研究学会会员

研究领域和方向

1. 骨关节炎和骨质疏松的分子遗传学分析;

2. 骨骼细胞分化的转录调控分析;

3. 骨髓间充质干细胞在骨骼发育和疾病中的作用研究

 发表文章:
1) Lingling  Zhang; Hanjun Li; Jian  Yu; Jingjing  Cao; Huihui Chen; Haixia  Zhao; Jianzhi  Zhao; Yiyun Yao; Lifang  Wang; Rujiang  Zhou; Zhengju  Yao, Xizhi Guo* (2014) Ectodermal Wnt signaling regulates abdominal myogenesis during ventral body wall development. Developmental Biology 387: 64–72
2) Wenrong Zhou, Huang Zhu, Jinazhi Zhao, Hanjun Li, Yong Wan, Jingjing Cao, Haixia Zhao, Jian Yu, Rujiang Zhou, Yiyun Yao, Lingling Zhang, Lifang Wang, Lin He, Gang Ma, Zhengju Yao, Xizhi Guo* (2013) Misexpression of Pknox2 in mouse limb bud mesenchyme perturbs zeugopod development and deltoid crest formation. PLoS One. 8(5):e64237
3) Yong Wan,Cheng Lu, Jingjing Cao, Rujiang Zhou, Yiyun Yao,Jian Yu,Lingling Zhang, Haixia Zhao, Hanjun Li, Jianzhi Zhao, Xuming Zhu, Lin He, Yongzhong Liu, Zhengju Yao, Xiao Yang and Xizhi Guo* (2013) Osteoblastic Wnts differentially regulate bone remodeling and the maintenance of bone marrow mesenchymal stem cells. Bone. 55(1):258-67
4) Cheng Lu, Yong Wan, Jingjing Cao,Xuming Zhu, Jian Yu,Rujiang Zhou, Yiyun Yao, Lingling Zhang, Haixia Zhao, Hanjun Li, Jianzhi Zhao, Lin He, Gang Ma, Zhengju Yao, and Xizhi Guo*(2013) Wnts-mediated reciprocal regulation between cartilage and bone development during endochondral ossification. Bone. 53(2):566-74.
5) Huang Zhu, Jianzhi Zhao, Wenrong Zhou, Hanjun Li, Rujiang Zhou, Lingling Zhang, Haixia Zhao, Jingjing Cao, Xuming Zhu, Hongliang Hu, Gang Ma, Lin He, Zhengju Yao, Libo Yao, Xizhi Guo* (2012) Ndrg2 regulates vertebral specification in differentiating somites. Developmental Biology. 369(2):308-18.
6) Xuming Zhu, Huang Zhu, Lingling Zhang, Sixia Huang, Jingjing Cao, Gang Ma, Guoying Feng, Lin He, Yingzi Yang, Xizhi Guo* (2012) Wls-mediated Wnts differentially regulate distal limb patterning and tissue morphogenesis. Developmental Biology. 365(2):328-38.
7) Sixia Huang, Xuming Zhu, Yanfang Liu, Yixin Tao, Guoyin Feng, Lin He, Xizhi Guo*, Gang Ma (2012) Wls Is Expressed in the Epidermis and Regulates Embryonic Hair Follicle Induction in Mice. PLoS One. 7(9):e45904.
8) Lin An, Xiwen Zhao, Jian Wu, Jianguo Jia, Yunzeng Zou, Xizhi Guo, Lin He, Hongxin Zhu (2012) Involvement of autophagy in cardiac remodeling in transgenic mice with cardiac specific over-expression of human programmed cell death 5. PLoS One. 7(1):e30097
9) Jun Yang, Shengying Qin, Chengqing Yi, Gang Ma, Huang Zhu, Wenrong Zhou, Yuyu Xiong, Xuming Zhu, Yujiong Wang, Lin He, Xizhi Guo* (2011). MiR-140 is co-expressed with Wwp2-C transcript and activated by Sox9 to target Sp1 in maintaining the chondrocyte proliferation. FEBS Letter Oct 3;585(19):2992-7.
10) Gang Ma, Jiang Yu, Yue Xiao, Danny Chan, Bo Gao, Jianxin Hu, Yongxing He, Shengzhen Guo, Jian Zhou, Lingling Zhang, Linghan Gao, Wenjuan Zhang, Yan Kang, Kathryn SE Cheah, Guoyin Feng, Xizhi Guo, Yujiong Wang, Cong-zhao Zhou and Lin He (2011). Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels. Cell Research. Sep;21(9):1343-57.
11) Lun Yang, Kejian Wang, Jian Chen, Anil G. Jegga, Heng Luo, Leming Shi, Chunling Wan, Xizhi Guo, Shengying Qin, Guang He, Guoyin Feng, Lin He (2011). Exploring off-targets and off-systems for adverse drug reactions via chemical-protein interactome--clozapine-induced agranulocytosis as a case study. PLoS Comput Biol. 2011 Mar; 7(3):e1002016.
12) Yue Xiao, Lingling Zhang, Kuanjun He, Xiang Gao, Lun Yang, Lin He,Gang Ma, Xizhi Guo* (2011). Characterization of a novel missense mutation on murine Pax3 through ENU mutagenesis. Journal of Genetics and Genomics, 38 (2) 333-339.
13) Zhengfeng Yang, Chenghai Li,Xiu Wang, Chunyan Zhai, Zhengfang Yi, Lei Wang, Bisheng Liu, Bing Du, Huihui Wu, Xizhi Guo, Mingyao Liu, Dali Li, Jian Luo (2010). Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF-kappaB signaling pathway in colon cancer cells. J Cell Physiol. Oct;225(1):266-75
14) Xizhi Guo, Kingston Kunlun Mak, Makoto Taketo, Yingzi Yang (2009). The Wnt/beta-catenin pathway interacts differentially with PTHrP signaling to control chondrocyte hypertrophy and final maturation. PLoS One. 26;4(6):e6067.
15) Chuwen Lin, Xuan Jiang, Zhongquan Dai, Xizhi Guo, Yinghui Li, Tujun Weng, Jun Wang, Guoyin Feng, Xiang Gao, Lin He (2009). Sclerostin Mediates Bone Response to Mechanical Unloading via Antagonizing Wnt/beta-Catenin Signaling. J Bone Miner Res. Oct;24(10):1651-61
16) Jian Zhou, Junwei Meng, Shenzhen Guo, Bo Gao, Gang Ma, Xuming Zhu,Jianxin Hu, Yue Xiao, Chuwen Lin, Hanyi Wang, Lushen Ding, Guoyin Feng, Xizhi Guo, Lin He (2007). IHH and FGF8 coregulate elongation of digit primordia. Biochem Biophys Res Commun. 363(3):513-8.
17) Xianzhong Feng, Zhao Zhong, Zaoxia Tian, Yonghai Luo, Zhigang Cai Z, Jun Yang, Zeng Wang, Lin Weng, Jianghua Chen, Liying Zheng, Xizhi Guo, Jianghong Luo, Sato S, Tabata S, Wei Ma, Cao X, Xiaohe Hu, Congrong Sun, Da Luo (2006). Control of petal shape and floral zygomorphy in Lotus japonicus. Proc Natl Acad Sci U S A. 103(13): 4970-5.
18) Timothy F. Day**, Xizhi Guo**, Lisa Garrett-Beal and Yingzi Yang. (2005) Wnt/β-Catenin Signaling in Mesenchymal Progenitors Controls Osteoblast and Chondrocyte Differentiation during Vertebrate Skeletogenesis. Developmental Cell 8 (5): 739-750 (** authors contribute equally to the paper)
19) Xizhi Guo, Timothy F. Day*, Xueyuan Jiang, Lisa Garrett-Beal, Lilia Topol and Yingzi Yang. (2004) Wnt/?-catenin signaling is sufficient and necessary for synovial joint formation. Gene & Development 18:2404-2417
20) Xizhi Guo, Zhong Zhao, Jianghua Chen, Xiaohe Hu, Da Luo. (2005). A putative CENTRORADIALIS/TERMINAL FLOWER 1-like gene, Ljcen1, plays a role in phase transition in Lotus japonicus. Journal of Plant Physiology. 163(4): 436-44

承担的科研项目
1) 首席科学家:信号通路对骨骼发育及相关疾病影响的分子机理研究,科技部重大科学研究计划项目(2007CB947300, 2007-2011),项目资助2400万,结题。
2) 项目负责人:miRNA在骨关节炎病理发生过程中的作用,上海市科委浦江人才计划项目(08PJ1407200, 2008-2010),项目资助18万,结题。
3) 项目负责人:Foxp1/2/4蛋白家族在骨骼发育和疾病形成过程中的作用研究,自然科学基金面上项目,(31171396, 2012-2015), 项目资助63万,在研。
4) 项目负责人:Ndrg1/2/4基因家族在调控脊椎骨结构形成过程中的作用, 自然科学基金面上项目,(31271553, 2013-2016), 项目资助80万,在研。
5) 技术骨干:Wnt信号蛋白在骨髓微环境中的作用,国家重大科学研究计划子课题,(BQ0890002,2011-2014),项目资助90万,在研。
6) 973重大科学研究计划项目课题负责人:脊柱形态建成及发育畸形的细胞与分子机制研究;项目编号2014CB942902;期限:2014-2018;项目资助200万

荣誉:
2008 上海“浦江人才”计划获得者
2005 美国骨骼及骨矿物质研究学会青年科学家奖
2005美国国立卫生研究院优秀博士后杰出研究奖

参与国际会议
1) 2012 Annual meeting of American Society for Bone and Mineral Research, Minneapolis, Minnesota, USA, poster “Foxp1/2/4 complex regulate osteoblast differentiation and chondrocyte hypertrophy”.
2) 2011 Annual meeting of American Society for Bone and Mineral Research, San Diego, USA, poster presentation, “The niche role of osteoblastic Wnts in bone remodeling and BMSC maintenance”.
3) 2011 Wnt meeting, Los Angels, USA, poster presentation, “The niche role of osteoblastic Wnts in bone remodeling and BMSC maintenance”.
4) 2010 Wnt meeting, Stockholm, Sweden, oral presentation, “Ectodermal and mesodermal Wnts differentially regulate distal limb morphogenesis”
5) 2010 Annual meeting of American Society for Bone and Mineral Research, Oronto, Canada, oral presentation, “The role of Wnt signaling mediated by Wntless in limb patterning”
6) 2010 Animal Model and Human Health meeting, Nanchang, oral presentation, “SCF/c-Kit signaling acts as a new etiological factor for depression by regulating adult hippocampal neurogenesis”
7) 2010 Molecular Cell Biology Symposium, Hangzhou, oral presentation, “The role of Wnt signaling mediated by Wntless in skeletal development”
8) 2010 Bio-X Symposium on Skeletal Developmental and Disorders, Shanghai, oral presentation, “The role of Wnt signaling mediated by Wntless in skeletal development”
9) 2009 Mouse Functional Genomics meeting, Shanghai, oral presentation,  “The role of Wnt signaling in skeletal development and mechanotransduction”
10) 2008 Annual meeting of American Society for Bone and Mineral Research, Montreal, Canada
11) 2006 Annual meeting of American Society for Bone and Mineral Research, Nashvile, USA, poster, “The role of canonical Wnt signaling in promoting chondrocyte hypertrophy and maturation”
12) 2005 Mouse Molecular Genetics, New York, USA, poster, “Wnt/β-catennin signaling is necessary and sufficient for synovial joint formation”