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科研团队(临床科室)王继峰
发布日期.[2015-01-23] 来源:  浏览:26318

个人简介:

生物化学与分子生物学博士。2008年毕业于厦门大学,获博士学位,师从林圣彩、沈月毛教授,先后在香港科技大学生物化学系做Research Assistant,复旦大学生命科学学院遗传所做博士后研究,上海肿瘤研究所、肿瘤医院做助理研究员,目前在复旦大学附属上海市第五人民医院泌尿外科做助理研究员。

研究方向:

一直从事信号传导通路和药物研发的研究。目前,正结合本院泌尿外科特色专科的临床优势,以前列腺癌的发病机制以及治疗为研究重点,深入开展相关研究。

科研成果:

先后发表SCI论文6篇。目前正申请发明专利2项。现主持国家自然科学基金青年基金项目1项和上海市科委课题1项。

发表论文::
1. Zhenyu Li, Lejiao Jia, Jifeng Wang, Xingkang Wu, Huilin Hao, Hongjiao Xu, Yunfei Wu, Guowei Shi, Chunhua Lu, Yuemao Shen. Design, synthesis and biological evaluation of 17-arylmethylamine-17-demethoxygeldanamycin derivatives as potent Hsp90 inhibitors. European Journal of Medicinal Chemistry, 2014; 85:359-370 ( DOI: 10.1016/j.ejmech.2014.07.101).
2. Zhenyu Li, Lejiao Jia, Jifeng Wang, Xingkang Wu, Guowei Shi, Chunhua Lu,Yuemao Shen * Discovery of Novel 17-Phenylethylaminegeldanamycin Derivatives as Potent Hsp90 Inhibitors. Chem Biol Drug Des. 2014.
3. Nansong Liu , Jiadong Wang , Jifeng Wang, Rukai Wang, Zhongle Liu, Hong Lu* ING5 is a Tip60 cofactor that acetylates p53 in response to DNA damage. Cancer Res. 2013;73:3749-3760.
4. Jifeng Wang, Yuting Yi, Wei Zhang, Baobing Zhao, Xuan Wu, Lianru Zhang,Yuemao Shen* Mycoepoxydiene, a fungal polyketide inhibits MCF-7 cells through simultaneously targeting p53 and NF-kappaB pathways. Biochem Pharmacol.2012;84:891-899.
5. Jifeng Wang,Baobing Zhao, Wei Zhang, Xuan Wu, Ruoyu Wang, Yaojian Huang, Dong Chen, Kum Park, Bart C. Weimer, Yuemao Shen* Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells. Bioorg Med Chem Lett. 2010;20:7054-7058.
6. Shuyong Lin, Jifeng Wang, Zhiyun Ye, Nancy Y. Ip, Sheng-Cai Lin,* CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5. FEBS Lett. 2008;582:1197-1202.
7. Qinxi Li, Xuan Wang, Xiaoling Wu, Yanning Rui, Wei Liu, Jifeng Wang, Xinghao Wang, Yih-Cherng Liou, Zhiyun Ye and Sheng-Cai Lin* Daxx cooperates with the Axin/HIPK2/p53 complex to induce cell death. Cancer Res. 2007;67:66-74.
8. Wei Liu, Hongliang Rui, Jifeng Wang, Shuyong Lin, Ying He, Mingliang Chen,Qinxi Li, Zhiyun Ye , Suping Zhang, Siu Chiu Chan, Ye-Guang Chen, Jiahuai Han and Sheng-Cai Lin* Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J.2006;25:1646-1658.